The Moderating Role of Drinking Water Habit on the Effect of High- Purine Dietary Intake on Uric Acid Levels in Adults and the Elderly

Authors

DOI:

https://doi.org/10.26699/jnk.v12i3.ART.p259-269

Keywords:

Drinking Water, High-Purine Diet, Hydration, Uric Acid, Hyperuricemia

Abstract

Serum uric acid levels are affected by dietary patterns and lifestyle factors. High-purine food consumption is a primary contributor to hyperuricemia, while hydration status may moderate this effect. This study aimed to examine the moderating role of drinking water habits on the relationship between high-purine dietary intake and serum uric acid levels among adults and the elderly. A cross-sectional design with purposive sampling was conducted, involving 87 respondents from Elderly Integrated Health Post (Posyandu Lansia). Data on purine-rich food intake and water-drinking habits were collected via structured questionnaires, and serum uric acid levels were measured using a point-of-care testing (POCT) device (Easy Touch GCU 3-in-1) with compatible test strips. Multiple logistic regression analysis assessed the interaction between purine intake and drinking water habits. Results revealed a significant association between high-purine dietary intake and elevated serum uric acid levels (p = 0.022). Participants who reported high-purine dietary habits along with insufficient water consumption demonstrated the highest prevalence of hyperuricemia (71.4%), whereas those with similar dietary patterns but adequate hydration showed a substantially lower prevalence (20.0%). A significant interaction effect (p = 0.040) indicated that sufficient water intake moderated the impact of a high-purine diet on uric acid levels. Adequate hydration thus plays a critical moderating role in reducing the adverse effects of a high-purine diet. Promoting sufficient water intake may serve as a simple and effective behavioral strategy to prevent hyperuricemia, particularly among individuals with high purine consumption.

Author Biographies

Anita Rahmawati, STIKes Patria Husada Blitar


Anita Rahmawati
mceclip1-1394c5616cc9c3b3eb04c6d162ea0751.pngSTIKes Patria Husada Blitar, Indonesia
Expertise: Nursing and Health Profession
(mceclip0-e415beefedcc2cbc460fc317cd250687.pngGoogle Scholar, mceclip1-975ef1beb0c6625c6f01d054f6f406d8.pngSinta, mceclip2-46336d215526dca6c673e9b2e01752cd.pngORCID)

Ulfa Husnul Fata, STIKes Patria Husada Blitar


Ulfa Husnul Fata
mceclip0-af26a06474514d7fdd2065fcea913df4.pngSTIKes Patria Husada Blitar, Indonesia
Expertise: Nursing and Health Profession
(mceclip9.pngGoogle Scholar, mceclip10.pngSinta, mceclip11.pngORCID)

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Published

20-12-2025

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Rahmawati, A., Lestari, A. A. D., & Fata, U. H. (2025). The Moderating Role of Drinking Water Habit on the Effect of High- Purine Dietary Intake on Uric Acid Levels in Adults and the Elderly. Jurnal Ners Dan Kebidanan (Journal of Ners and Midwifery), 12(3), 259–269. https://doi.org/10.26699/jnk.v12i3.ART.p259-269

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Vol. 12 No. 3 (2025)

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